Circumstances verified as the several maternity, unfinished medical records, and you will nutritional D peak registered after thirteen days away trovare donna latina from gestation were excluded
This study aimed to investigate the relationship between maternal serum vitamin D status in the first trimester of pregnancy and maternal as well as neonatal outcomes, considered the prevalence of vitamin D deficiency (serum 25(OH)D < 50 nmol/L) around the world, especially in the pregnant women.
Procedures
Away from , within this mix-sectional retrospective research, i enrolled females searching normal prenatal examinations and giving birth inside the brand new Global Peace Maternity and you will Child Wellness Healthcare. All in all, 23,394 mother-kid pairs had been incorporated at some point. Obstetric and you can neonatal suggestions have been extracted from brand new database. Maternal gel supplement D quantity was counted by chemiluminescence microparticle immunoassay. Logistic regression research (unadjusted and you may modified designs) was used to research the newest relationship between supplement D and you may maternal and neonatal consequences.
Results
The average 25(OH) D concentration was ± 0.10 nmol/L; % of patients were vitamin D deficient(25(OH) D < nmol/L), % were vitamin D insufficient (50 nmol/L ? 25(OH)D < 75 nmol/L), 3.07% were sufficient (25(OH)D ? 75 nmol/L). The maternal 25(OH)D levels varied with age, pre-pregnancy BMI, season when blood sample was collected, number of previous-pregnancy. Notably, newborns delivered by women with deficient vitamin D status had a higher incidence rate of admission to NICU (Deficiency: % vs Insufficiency: % vs Sufficiency: %, Pbonferroni = .002) and a longer stay (deficiency: 6.2 ± 4.1 days vs insufficiency: 5.9 ± 3.1 days vs sufficiency: 5.1 ± 2.1 days, Pbonferroni = .010). Moreover, maternal vitamin D deficiency was a dependent risk factor for admission to NICU (unadjusted OR = 1.35, 95% CI,1.05–1.74 Pbonferroni = .022; adjusted OR = 1.31, 95% CI,1.010–1.687 Pbonferroni = .042).
Conclusions
Maternal vitamin D deficiency (25(OH) D < 50 nmol/L) was prevalent in eastern coastal China. The incidence rate of GDM as well as preeclampsia was higher in vitamin D insufficient group while vitamin D deficiency group was liable to intrauterine infection when compared with the other two groups. Most importantly, low vitamin D status in the first trimester of pregnancy was a dependent risk factor for admission to NICU. More well-designed perspective researches are necessary to clarify the role of vitamin D in the early stage of pregnancy.
Addition
Vitamin D, with a vital role in calcium absorption and bone metabolism, also functioned in cell proliferation and differentiation, affecting the immune system as well . However, it’s worrisome that the incidence of vitamin D deficiency (VDD) is prevalent globally, especially in pregnant women . Low vitamin D status (defined as serum 25(OH)D concentrations < 50 nmol/L) was found in 33% of pregnant women in the US and 24% in Canada, respectively. Read more…?